Aging Gracefully, Powerhouse Peptides + Shifting Society’s Script For Skin Health | Alessandra Zonari (OneSkin)

Wellness + Wisdom | Episode 636

What is the secret ingredient to aging gracefully?

Aging Gracefully, Powerhouse Peptides + Shifting Society's Script For Skin Health | Alessandra Zonari (OneSkin)Alessandra Zonari, Scientist and Co-Founder of OneSkin, joins Josh Trent on the Wellness + Wisdom Podcast, episode 636, to unpack how skin health impacts your health and longevity, why senescent cells are behind visible aging, and how the revolutionary peptide developed by OneSkin helps your skin thrive.

“You age better when you are feeling good about yourself. Aging is a malleable process. It's more about our choices and lifestyle, and we can bring science to help us to age better.”Alessandra Zonari

15% Off OneSkin


All OneSkin Topical Supplements are formulated with OS-01, the first ingredient scientifically proven to reverse skin’s biological age at the molecular level.

OneSkin team screened over 900 peptides to develop OS-01: The first peptide proved to reverse skin’s biological age by reducing senescent cell accumulation.

Their proprietary technology, including the rigorous in-house R&D process and the OS-01 peptide, is supported by 4 peer-reviewed scientific publications and 14 patent publications, with more coming.

In This Episode, Alessandra Zonari Uncovers:

[01:30] Skin Health + Longevity

[08:30] Skin Thinning + Inflammation

  • Every step of your life leads you to the thing you're meant to do.
  • The epidermis is the largest organ in the human body.
  • The layers of skin that protect our internal body.
  • How skin can contribute to inflammation.
  • Why our skin gets fragile and thin as we age.

[14:50] Senescent Cells Make You Age Faster

  • The five layers of the epidermis.
  • Why senescent cells start causing inflammation as we get older.
  • How UV light and diet affect senescent cells.
  • A healthy lifestyle is crucial for healthy skin.
  • How OneSkin formulated a peptide product that can help reduce senescent cells in your skin.

[20:40] Peptides for The Skin

  • How peptides support the skin with amino acids.
  • Josh's and Lauren's experience using OneSkin products.
  • OneSkin's skincare is validated by scientific research.
  • Why they're not a beauty company but a wellness company.

[27:35] Skin Health Begins on The Inside

  • The inner and outer care we need to feel and be well.
  • Many skin products are toxic.
  • How the skin reacts to the food we eat.
  • Our skin tells us what's going on on the inside.

[32:50] Measure Your Biological Age

[36:40] The Skin Microbiome

[42:45] Aging Gracefully

  • How society creates false narratives around aging.
  • Why OneSkin is not anti-aging but pro-longevity.
  • It's important to feel good as we age, instead of trying to go against it.
  • How we have old age associated with disabilities.
  • What we can learn from Blue Zones.

[46:50] Exercise + Thoughts Impact Your Skin

  • How mothers can take care of themselves to age gracefully.
  • Physical exercise changes how we age and how we feel mentally and emotionally.
  • Why Alessandra wouldn't want to be 20 again.
  • If we change the way we think, we can change how we age.

[50:10] Science + Feminine Energy

  • Why the feedback from customers fuels Alessandra to keep doing more research and developing the company.
  • What she loves about science.
  • How the world is accepting the expression of feminine energy.
  • Why OneSkin didn't plan to launch their own product.

[57:15] Wholeness Comes from Wellness

  • Why OneSkin keeps conducting research after the product has been launched.
  • We can't have wholeness without wellness.
  • We need to think of our wellness in the long run.

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Power Quotes From The Show

OneSkin Is Pro-Longevity

“At OneSkin, we are not anti-aging, we are pro-longevity. What we want to bring to people's life is the empowerment on aging and helping them get a skin that's strong to navigate the path of aging.”Alessandra Zonari

Get Rid of Senescent Cells

“What we did at OneSkin was research a new molecule that could reduce the senescent cells in the skin that secreting inflammation. When we are young, our body removes the cells and the tissue restores the homeostasis. But as we age, some of the cells don't die. And that constant release of inflammation start deteriorating the healthy environment around that cell.”Alessandra Zonari

The Skin Protects Your Organs

“Our skin is protecting all our organs internally from all the stressors in the environment. It's a very important organ that keeps the homeostasis of our body.”Alessandra Zonari

Links From Today's Show 

Josh's Trusted Products | Up To 40% Off


Nutrition + Gut Health


Fitness + Physical Health

Healthy Home

Mental Health + Stress Release

Personal Care

About Alessandra Zonari

Aging Gracefully, Powerhouse Peptides + Shifting Society's Script For Skin Health | Alessandra Zonari (OneSkin)Alessandra Zonari holds a Biological Sciences degree with a Master's and Ph.D. in Stem Cell and Regenerative Medicine.

Her expertise is in skin regeneration, stem cell differentiation, and tissue engineering. During her period in Portugal, she co-founded Vetherapy, a biotech company that provides stem cell therapies to treat diseases for pets.

At the beginning of 2017, Alessandra moved to San Francisco, CA to join the early team of OneSkin as a Co-Founder and Chief Scientific Officer.

At OneSkin she has dedicated herself to understanding the mechanism that underlies the aging process and to develop science-based solutions that maximize our healthspan. She is a co-inventor of three patents and has published over 20 peer-reviewed papers in scientific journals.

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About Josh Trent

Josh Trent lives in Austin, Texas with his love Carrie Michelle, son Novah, daughter Nayah + a cat named Cleo. He is the host of the Wellness + Wisdom Podcast and the creator of the BREATHE: Breath + Wellness Program. Josh has spent the past 20+ years as a trainer, researcher + facilitator discovering the physical and emotional intelligence for humans to thrive in our modern world. Helping humans LIBERATE their mental, emotional, physical, spiritual + financial self through podcasts, programs + global community that believe in optimizing our potential to live life well.

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