Dr. John Lieurance | Melatonin Miracle: Supra-Physiologic Dosing, Sinus Health & Ending Inflammation


“Melatonin is an absolute miracle molecule. We would not be able to enjoy life without this molecule. Every cell in the body makes it and it's there within a structure called the mitochondria. The structure is vital because the mitochondria is where rubber meets the road as far as making energy in the body.” – Dr. John Lieurance

Wellness + Wisdom Episode 436

Naturopath & Chiropractic Neurologist at Advanced Rejuvenation and Ultimate Cellular Reset, Author of Melatonin: Miracle Molecule, and of MitoZen, Dr. John Lieurance, shares his healing protocols including the Meditation Mist, how the substances of oxytocin and hapé can improve sinus health plus calm the nervous system, how our nerves work and what they require for activation and fuel, as well as the myths and truths of melatonin.

What comes to mind when you hear the word, “rejuvenation“? What does it actually mean to you?

Maybe it makes you think of a return to innocence or about how we can end inflammation for good?

With a myriad of groundbreaking and cutting-edge scientific practices including a nasal spray that I have been using for the last 3 months, Dr. John is changing the way we heal chronic disease.

Melatonin is an absolute miracle molecule. We would not be able to enjoy life without this molecule. Every cell in the body makes it and it is key for helping produce energy in the body's mitochondria. - Dr. John Lieurance (@awcsarasota)Click To Tweet

MitoZen Nasal Spray + More!

Dr. John Lieurance | Melatonin Miracle: Supra-Physiologic Dosing, Sinus Health & Ending InflammationEvery single night before we go to bed, my partner Carrie Michelle and I perform a beautiful ritual using the ZEN extra strength + Oxytocin.

It is what I believe the world needs right now: a centered, calm, and powerful third eye opening meditation tool that will change the fundamentals of your practice.

ZEN Nasal Spray™ is the strongest formula, and is made from different medicinal plants from the Amazon to calm and quiet the mind, as well as to reduce anxiety and stress.

The ZEN EO Nasal Spray™ is made with Ultra Nano Liposomal terpenes & essential oils. ZEN CBD Nasal Spray™ contains essential oils, terpenes and full spectrum NeuroHEMP™.

The Zen formulas are powerful in the ability to calm the mind and allow for maximum vagal activation (stimulation of the vagal nerve).

You will experience a powerful afterglow effect, following the initial temporary burning feeling after administration.

*Go to wellnessforce.com/MitoZen to get your ZEN extra strength + Oxytocin.
*Be sure to select ZEN extra strength + Oxytocin at the cart.


Listen To Episode 436 As Dr. John Lieurance Uncovers:

[1:30] Advanced Rejuvenation Healing Protocols

  • Dr. John Lieurance
  • MitoZen – Save 10% with the code ‘WELLNESSFORCE'
  • Melatonin: Miracle Molecule by Dr. John Lieurance
  • Advanced Rejuvenation
  • Ultimate Cellular Reset
  • How Josh and Dr. John connected in the wellness world.
  • What Dr. John's Meditation Mist is and how it has become so powerful for Josh's breathwork practice.
  • The difficult childhood Dr. John and his sister had as his parents worked to heal their own struggles, improve their relationship, and navigate life.
  • Dr. John's obstacles with being hyperactive, dyslexic, and having learning disabilities which alienated him in school and in the world.
  • The incredible support that his mother gave him as he grew up by believing in him and being there for him when he needed it the most.
  • How helping him also guided his mother to grow out of her own shell.
  • His relationship with his father as he worked as a Marine and though he is more withdrawn, they have a beautiful, supportive relationship.
  • The work that Dr. John does at his clinic with his homeopathic and chiropractic training where he offers RejuvenOX Protocol, LumStem therapy, and Stem Wave Regenerative Medicine.
  • How he brought the Advanced Rejuvenation clinic to life.
  • Why all disease is rooted in one core issue which is energetic and metabolic: the ability of the cell to derive energy from sugar and oxygen.
  • Understanding how unique experiences of stress inflame the body from sunburns and parasites to COVID-19.

[16:00] Hapé, Meditation Mist & Breathwork

  • How his clinic is growing and their plans for the future.
  • The fact that some patients sometimes stay with them for over a week to utilize all they have to offer to help them heal.
  • Exploring the most common disorders or illnesses people have who seek out help at Advanced Rejuvenation.
  • The power of pausing and asking yourself, ‘Am I a river or a swamp?' – is the body draining properly or are things stagnate?
  • Why many healing modalities focus on improving circulation and drainage in the body so that it operates like a river.
  • Dr. John's experience with plant medicine and how he wanted to bring that healing experience of hapé back to his patients with his Meditation Mist.
  • How you traditionally use hapé and why the experience can be rough for some people who aren't used to it.
  • Other ways to use hapé that aren't too overwhelming when you use it in smaller doses.
  • How Dr. John has helped Josh with his sinus issues by doing a balloon sinus adjustment (endonasal balloon adjustment) for him.
  • The science behind hapé and the incredible benefits you can receive from it.
  • What ingredients you will find in Dr. John's ZEN Nasal Spray and its powerful impact on the body especially with supporting the parasympathetic nervous system.
  • Why breathwork is such a powerful tool to help our body flow like a river, reduce stress, and strengthen our parasympathetic nervous system.
  • How mental and emotional stress in our go-go-go world is a movement away from the parasympathetic nervous system.

[28:30] Understanding & Strengthening The Nervous System

  • Breaking down how our nerves work and why they require activation as it fuels them.
  • Why it's so important to fire up and use our nerves otherwise we could lose them.
  • How we can strengthen our nerves based on how often they're being used.
  • The incredible ability we have to create new connections with our nerves especially when we take ice baths or do breathwork.
  • Why it's important to always be introducing unique and novel modalities to the body.
  • Exploring why it might not be the best thing to do the same modality every single day because then you're stuck in the familiar zone.
  • How to get out of the danger and familiar zone so that you're in the homeotic, sweet spot zone to create just enough stress for a net gain in your health.
  • Understanding how much stress your body can take before it begins to break down and how to condition that to raise the ceiling.
  • How methylene blue, ozone therapy, or melatonin can help you condition the body and raise the ceiling for how much stress your body can take for greater benefits.
  • Why Dr. John specifically chose to include Oxytocin in the ZEN Nasal Spray for its anti-inflammatory properties for the brain.
  • His family's history and the belief that every fourth generation brings forth an artist and he actually left his medical practice to paint full time.
  • Why he felt called to medicine and never thought he would be where he is now today.
  • The immense amounts of gratitude that he has been feeling lately with his purpose in serving others and everything that has been happening around him and his community lately.

[37:30] Going With The Flow of Life

  • Dr. John's own wellness journey having experienced mold exposure and Lyme disease which caused him so much physical pain.
  • Joseph Campbell
  • Dr. Daniel Pompa
  • Dr. John's “from pain to purpose” story and why he wouldn't change a single thing about it.
  • Why you are exactly where you need to be right now especially if you're in your own pain to purpose story.
  • Life is NOT a Journey – Alan Watts
  • Dr. Michael Ryce
  • How we can go through the process of deeply forgiving ourselves and the “filter” we all have that shifts the way we see reality based on our unconscious belief systems.
  • Why our goals drive our unconscious belief systems and how to cancel our goals and drop into what is real and actually happening.
  • Josh's old belief that if he forgave someone, then they would win, and how his view on that has shifted.

[43:30] Myths and Truths of Melatonin

  • How melatonin, when taken correctly, can help a person with their stress and sleep.
  • Common myths about melatonin and why many people are so unaware of the truths of this supplement.
  • The science of melatonin and how it works with the body's biology.
  • Why melatonin is the primary antioxidant that quenches the body when it overheats.
  • The powerful connection between melatonin and our gut health.
  • Why melatonin is not dangerous for the body even when taken in high doses.
  • The typical dosage of people is 2-10 mg of melatonin but he believes people should be taking more as it does so much to help us beyond sleep.
  • How melatonin in the body drops significantly as we get older.
  • Why it is very important to create an atmosphere and routine at home that will help your circadian rhythm but we cannot just rely on our body's own melatonin secretion.
  • The Warburg Effect: How Does it Benefit Cancer Cells?
  • Why many hospitals have begun to use very high dosages of melatonin to treat patients.
  • How melatonin has been used in high dosages to treat other very dangerous infections including Ebola.
  • Breaking down why you won't become addicted to melatonin but you should speak with your medical practitioner to decide the right amount of dosage for you.

[55:30] The Importance of Sleep to Detox The Brain

  • The detox mechanism that happens in the brain when we achieve deep sleep.
  • How much deep sleep is optimal and how melatonin plays a role in it.
  • Why high dosages of melatonin is not the end all be all to keep you asleep the entire night.
  • SandMan Sol
  • The importance of keeping track of your sleep and trying out different methods to give you the best results for your unique body.
  • Why the body only absorbs about 2.5% of melatonin taken orally.
  • Breaking down which supplements are better not taken orally in order to get all of the benefits.
  • Why glutathione suppositories were such a vital aide for him when he had Lyme disease.
  • The power of glutathione and NAD suppositories to help the body heal.
  • Why their clinic began to do NAD IVs but a suppository is a much better experience for their patients.
  • 400 Cal Callahan
  • How these tools will also aid us with our emotional health to help us love and show up more.

[1:07:00] Melatonin & Our Pineal Gland

  • Exploring the structure of the pineal gland, its purpose, and how its relationship with melatonin.
  • How to protect and nourish the pineal gland.
  • Russel Ryder 1960s pineal gland to discover its importance – melatonin research
  • How fluoride can calcify the pineal gland.
  • The importance of having a water filter in your home and not using products like toothpaste with fluoride.
  • 184 Scott Nelson
  • HeartMath
  • 404 Jay Brown
  • Studies done on the heart to conclude that it can predict the future and seems to be the real brain and transcends time and space.
  • Letting Go by David R. Hawkins
  • The power of getting out of our heads and dropping into our hearts.

[1:15:00] Coming Back to Homeostasis

  • Why we shouldn't stress on things that are out of our control as it takes us out of our parasympathetic mode.
  • What will help you the most to come back home to self and be centered again: melatonin.
  • The importance of speaking to your health practitioner before trying anything new like melatonin.
  • 394 Adam Roa
  • The sinus protocol he has all of his patients go on for 30 days as part of their healing process.
  • Dr. John's own daily sinus health practice with a neti pot, iodine or colloidal silver, or even some of their GlutaStat if he is sick.
  • Why xylitol can be recommended for a sinus rinse.
  • James Nestor
  • 358 Dr. Belisa Vranich
  • Why it's so important to be able to breathe through your nose for overall health.
  • Sinus infections that people may be carrying such as MARCoNS and Dr. John's own experience with it.
  • Why he recommends getting tested for MARCoNS if you are experiencing very poor health.
  • The toxic effects of gentamicin and why you never want to take it as it can be bad for your inner ear with severe tinnitus and lead to other health issues.
  • 428 Dr. Ben Lynch
  • Benefits of nebulizing a substance like GlutaStat to help you breathe that in better.

[1:23:30] The Future of Naturopathic Care

  • How Dr. John operates in a safe way with his clinic in Florida when the mainstream medical industry pushes against what he is doing.
  • What is CRISPR?
  • What he is excited about the most for naturopathic care and humanity's future.
  • His interest in metabolic medicine and why he thinks that is the future.
  • Why the structure of cellular energy is absolutely necessary for our health.
  • What methylene blue is, why Josh has been experimenting using it, and the benefits of it.
  • How researchers discovered that methylene blue can kill parasites and was actually the first FDA-approved drug for malaria.
  • Why hydroxychloroquine was developed because people didn't like how the methylene blue turned their urine blue.
  • The fact that methylene blue can absorb very well but you want to absorb it slowly to avoid complications.
  • Why methylene blue can have some bad interactions with SSRIs.
  • The fact that there are incredible pharmaceuticals being shelved because they would heal chronic disease and sickcare businesses would lose customers.
  • 345 Zach Bush MD

[1:36:30] The Beneifts of NAD and NAD+

  • What NAD is and how to get the most out of it.
  • Why supplementing with NAD can be beneficial especially as you get older.
  • Studies that were done on laboratory animals supplementing NAD with good longevity results and assist with mitochondrial function.
  • The key differences between NAD and NAD+.
  • Josh's plan to compare his experience with oral and suppository melatonin supplements.
  • Positive benefits Dr. John's patients have experienced with suppositories over oral supplements.
  • What keeps Dr. John's mission going and what he's excited about the most.
  • 361 Luke Storey
  • His experience with the plant medicine, Bufo, and what it has taught him.
  • Why it's important to do daily wellness practices and try things like breathwork or ice baths before even considering a plant medicine ceremony.
  • How Dr. John has come to terms with his own greatest fears.
  • Field Trip Houston
  • Josh's experience with ketamine and why it was so different than his other experiences with psychedelics.
  • Paul Check | All is God

Power Quotes From The Show

All diseases are rooted in one issue which is an energetic, metabolic concern. It's the ability of the cell to derive energy from sugar and oxygen. When this system is not efficient, there is a lot of pollution. - Dr. John Lieurance (@awcsarasota)Click To Tweet

The Root of All Disease

“All diseases are really rooted in one core issue which is an energetic, metabolic concern. It's the ability of the cell to derive energy from sugar and oxygen. This is either efficient or not efficient; when it's not efficient there is a lot of pollution that starts to accumulate within the body and inflames it. All forms of stress are basically going to relate to some sort of inflammation. There is a fingerprint of every type of stress and how it inflames the body and those are a set of cytokines. A sunburn will have a different of cytokines than COVID-19 or a parasite infection in your gut.” – Dr. John Lieurance

The Business Side of Sickare

“Emergency medicine is a whole different deal; if I get a heart attack, I want to to go the hospital. However, if I have a chronic disease, I'm certainly not signing up to go on XYZ ten, twelve different medications for the rest of my life because it's not treating the problem. If you do that, you're basically just keeping the body in a chronic state of disease which brings us to look at the business side of sickcare. If companies are driven to come up with solutions for you that keep you in a chronic state of disease, they're not motivated to find solutions that will cure it because then they would lose the patient. There are dozens of great solutions that are being shelved because then they wouldn't make more money off of people. It's a crime.” – Dr. John Lieurance

Activating the Parasympathetic Nervous System

“Your autonomic nervous system consists of the parasympathetic and sympathetic nervous systems. We certainly don't need more of the sympathetic nervous system – this is your fight or flight zone and we've got enough stress already. What we really want and what we really need is more of our parasympathetic nervous system. This is the resting and digesting area but it is also the part of the nervous system that lights up when we feel more grounded and connected to Source. It helps you feel good and relaxed and experience bliss. We want to support that and when you use the ZEN nasal spray, it's a powerful activator to the vagus nerve which is the primary nerve that carries the parasympathetic nervous system. Like breathwork, it's a window to actually having some control over the autonomics.” – Dr. John Lieurance


Links From Today's Show 


About Dr. John Lieurance

Dr. John Lieurance | Melatonin Miracle: Supra-Physiologic Dosing, Sinus Health & Ending InflammationNaturopath & Chiropractic Neurologist, Dr. John Lieurance, has been in private practice for over 27 Years. Currently with Advanced Rejuvenation, a Multi Disciplinary Clinic, with a focus on Alternative & Regenerative Medicine, Naturopathic Medicine, Chiropractic Functional Neurology, Functional Cranial Release (FCR), Lumomed, Lyme Disease, Mold Illness and many other Neurological Conditions.

His treatments have been proven very successful for treating many chronic neurological and chronic infection conditions. He believes that toxins and infections are at the root of many conditions including Autoimmune, Parkinson’s, Alzheimer’s, Inner Ear Conditions, and most Degenerative Neurologic Conditions.

Books byDr. John Lieurance

He is the Author of Melatonin: Miracle Molecule and he's working on his second book on endonasal cranial therapy. As the developer of Functional Cranial Release, he teaches as well as certifies these methods to doctors around the world.

MitoZen Scientific

He is also the Chief Scientific Officer of MitoZen Scientific, a cutting-edge health care technology company that has a focus on powerful delivery systems such

Many of the products created are designed to be used for support for alternative practitioners to apply to chronic conditions such as mold toxicity (CIRS), heavy metal toxicity, autoimmune conditions, neurological diseases, and chronic inflammation.

Also, many “BioHackers” find them helpful to enhance cognition and physical performance!

Ultimate Cellular Reset

He is the Founder of UltimateCellularReset.com, a web-based educational portal, which sends out weekly videos on health and wellness tools for overcoming disease, longevity and vitality.

He has also contributed and appeared on many media outlets, and has been on the Documentary “Pain Revealed”, ABC 7 news, SNN news, as well as on popular podcasts like Ben Greenfield Fitness and CellTV with Dr. Dan Pompa.


Could it be Mold not Lyme?

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About Josh Trent

Josh Trent lives in Austin, Texas with his love Carrie Michelle, son Novah, and a cat named Cleo. He is the Founder of Wellness Force Media, host of the Wellness + Wisdom Podcast and the creator of the BREATHE: Breath & Wellness Program. Josh has spent the past 19+ years as a trainer, researcher, and facilitator discovering the physical and emotional intelligence for humans to thrive in our modern world. The Wellness Force Media Mission is to help humans heal mental, emotional, and physical health through podcasts, programs, and a global community that believes in optimizing our potential to live life well.

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